Colonial North America: Countway Library of Medicine

Holyoke, Edward Augustus, 1728-1829. Manuscript on smallpox inoculation by Edward Augustus Holyoke, undated. B MS Misc., Countway Library of Medicine.

Undated manuscript written by Dr. Edward Augustus Holyoke (1728-1829) regarding inoculation. He describes the various methods of inoculation used by physicians, ways to store inoculation matter, and how to treat patients after they are infected with smallpox including administering a cooling regimen recommended by English physician Thomas Sydenham, restricting animal-based food, and encouraging moderate exercise. Holyoke also writes that he administers calomel, compound powder of crab's claws, and cream of tartar to his patients six days after smallpox eruptions first appear.

Biographical Notes

Edward Augustus Holyoke (1728-1829), A.B., 1746, Harvard College, Cambridge, Massachusetts, was a physician in Salem and the son of Harvard's ninth president, Edward Holyoke (1689-1769). He studied medicine under Thomas Berry (1695-1756) of Ipswich, Massachusetts, and once Holyoke's practice was established in Salem, he took on pupils including future Harvard Medical School professors John Collins Warren (1778-1856) and James Jackson (1777-1867). Holyoke was also the first president of the Massachusetts Medical Society from 1782 to 1784.

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of the incision and infiction

By Enoculation ye infection is Propagated various ways: the most ususal is by a thread drawn thru a Ripe pustule of an infected Patient. If not used immediately it Should be dried in the Shade that the Contagious Matter May not acquire an acrimony which may increas the Symtoms.

An incision Should then be maid in the fleshy by part of the arme: so as first to Draw Blood and a piece of this infected thread Should be Laid in it and then Coverd with a Sticking Plaster or the –– infection may be preserved upon a Lancet which has been diped in a ripe pustel & Dried Before it is used. The miasmata may Long be kept on Such a Lancet. with this armed Lancet make an incision Between the Cutis & Cuticula pressing your finger upon the Lancet that the varilous Mater May be –– wiped off & Left under the scars Skin. Suttom method which is perhaps the best is this

Last edit almost 3 years ago by blackletterkate